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HerbMed® - an interactive, electronic herbal
database – which provides hyperlinked access
to the scientific data underlying the use of herbs
for health. It is an evidence-based information
resource for professionals, researchers, and general
public.
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Common Name :
Xi Shu
Latin Name :
Camptotheca acuminata
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| EVIDENCE FOR EFFICACY (HUMAN DATA) |
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Interactions |
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This study was designed to evaluate irinotecan (CPT-11) disposition and pharmacodynamics in the presence and absence of the broad-spectrum antibiotic neomycin. Kehrer 2001 |
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Contemporary Standardized Methods |
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Tumor cells that contaminate hematopoietic cell preparations contribute to the relapse of neuroblastoma patients who receive autologous stem cell rescue. This study details in vitro experiments to develop a prodrug purging method that specifically targets neuroblastoma cells. Meck 2001 |
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Irinotecan, 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) is activated by carboxylesterases (CE) to yield the potent topoisomerase I inhibitor, SN-38. Wierdl 2001 |
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Cyberbotanica |
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Contemporary Formulas |
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Breathing CO2-enriched aerosol increases pulmonary ventilation with concurrent increased deposition of inhaled particles. Liposome formulations of two anticancer drugs, paclitaxel (PTX) and camptothecin (CPT), were investigated for deposition of anticancer aerosols in mice. Koshkina 2001 |
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Pharmacokinetics (ADME) |
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Irinotecan is a semisynthetic derivative of camptothecine that has proved activity in the treatment of colorectal carcinoma. The hepatic extraction, metabolism, and biliary excretion of irinotecan in the isolated perfused rat liver was studied. Farabos 2001 |
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This study characterized the relationships between human plasma irinotecan carboxylesterase-converting enzyme activity and tested whether these in vitro tests to could predict the variability in SN-38 pharmacokinetics in adult patients during a prolonged infusion of irinotecan. Guemei 2001 |
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The intestinal transport of irinotecan and its active metabolite, SN-38, was previously reported. In the present study, the effect of the two major primary bile acids, cholic acid and taurocholic acid, on the uptake of CPT-11 and SN-38 by hamster intestinal epithelial cells was investigated. Kobayashi 2001 |
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Genetics & Molecular Biology |
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Camptothecin targets eukaryotic DNA topoisomerase I by trapping the covalent complex formed between the catalytically active enzyme and DNA. Using an Aspergillus nidulans mutant sensitive to camptothecin, other factors involved in mediating cellular sensitivity to camptothecin were investigated. Bruschi 2001 |
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Camptotheca acuminata in Mendel Plant Gene Nomenclature Database |
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