| EVIDENCE FOR EFFICACY (HUMAN DATA) |
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Clinical Trials |
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"Use of a herbal infusion of Origanum in hemophilia patients during tooth extraction " (Russian, no abstract) Klement 1978 |
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Observational Studies/Case Reports |
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Both the addition of oregano and the introduction of regular within-meal pauses enhanced overall food intake in human volunteers Yeomans 1997 |
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54 human volunteers eating pasta with a tomato sauce rated food attractiveness greatest with 0.27% oregano and least with 0.54% oregano
Yeomans 1996 |
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Traditional and Folk Use |
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Ethnobotanical survey of 130 informants in Israel revealed 16 species used for hypoglycaemia: Achillea, Ammi, Atriplex, Capparis, Ceratonia, Cleome, Eryngium, Inula, Matricaria, Origanum, Paronychia, Prosopis, Salvia., Sarcopoterium, & Teucrium Yaniv 1987 |
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"Origanum dictamus L., a Greek native plant " (no abstract) Skrubis 1979 |
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Pregnancy associated aversions were meats, poultry, and sauces flavored with oregano and cravings were ice cream, sweets, candy (esp chocolate), fruits, and fish - in a survey of 250 women
Hook 1978 |
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Contemporary Standardized Methods |
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Water steam distillation from acidic medium may give a better extraction if the volatile terpene derivatives are bound in form of glycosides or dimeric quajazolide lactones were present (oregano, Sideritis, wormwood oils) Lemberkovics 1998 |
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Microbe contamination of cinnamon and oregano used in Cuba was at acceptable levels, below 10(4) per gram, while black pepper and cumin were the most contaminated at 10(6) per gram
Rodriguez 1991 |
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Improved extraction of antioxidants by supercritical fluid extraction from Labiatae including Rosmarinus, Salvia, Thymus, Origanum; US Patent 5,017,397 |
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Microbial contamination of 150 oregano samples obtained in Buenos Aires
Fernandez 1984 |
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Solvent defatting for turmeric and oregano
Dent 1982 |
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Contemporary Formulas |
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Herbal pasta can be prepared with solids derived from oregano, basil, coriander, tarragon, onion, parsley, sage, garlic, etc.; US Patent 5,508,053 |
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Herbal pasta can be prepared with solids derived from oregano, basil, coriander, tarragon, onion, parsley, sage, garlic, etc.; US Patent 5,508,053 |
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Mastitis treatment with a water and ammonia extract of Matricaria, Calendulae, Urtica, Erythreae, Betula, Plantago, Pinus, Origanum, Salvia, Archangelica, Taraxacum, Tussilaginis, Sanguisorba, Valeriana, Menthae, Thymus, Bidens; US Patent 5,061,491 |
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Pharmacodynamics |
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Unsaturated oils stabilized against oxidation by essential oil of thyme, oregano, pepper or clove; US Patent 5,871,757 |
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Oregano inferior to DEET at repelling insects
Braverman 1998 |
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Aspergillus flavus on corn is inhibited by essential oils of Origanum vulgare, cinnamon, peppermint, basil, thyme, epazote or clove
Montes-Belmont 1998 |
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Clostridium (a foodborne pathogen) is inhibited by garlic, black pepper, cumin, oregano & bay
Rodriguez-Romo 1998 |
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Carvacrol showed a dose-related growth inhibition of the food-borne pathogen Bacillus cereus with total inhibition at 0.75 mM
Ultee 1998 |
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Progesterone receptor binding herbs were oregano, verbena, tumeric, thyme, red clover and damiana. Estrogen receptor binders were soy, licorice, red clover, thyme, tumeric, hops, and verbena
Zava 1998 |
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"Study of the antioxidative effects of thyme, sage, juniper and oregano " (no abstract) Takacsova 1995 |
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Mycelial growth of aflatoxin producing Aspergillus parasiticus is stopped by 0.1% cinnamon, thyme, oregano, or cumin essential oils; 0.2-1% coriander, black pepper, mugwort, bay, or rosemary essential oils. Curcurmin, citrus & ginger were inactive at 1%
Tantaoui-Elaraki 1994 |
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0.2% Agar suspension was sufficient to obtain a stable dispersion of oregano and clove essential oils in liquid media and was more toxic to microbes so studies using solvent dispersion underestimate antibiotic activity
Remmal 1993 |
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Lactobacillus plantarum and Leuconostoc mesenteroides were inhibited by oregano or cumin
Kivanc 1991 |
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Antioxidant activity of rosmarinic acid in various Lamiaceae: Rosmarinus, Salvia, Lycopus, Melissa, Origanum or Prunella
Lamaison 1991 |
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9 foodborne fungi were inhibited better by oregano than salt, thymol or carvacrol
Akgul 1988 |
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"Preliminary study of phenolic glycosides from Origanum majorana; quantitative estimation of arbutin; cytotoxic activity of hydroquinone " (no abstract) Assaf 1987 |
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8 yeasts are more sensitive to essential oils (allspice, cinnamon, clove, garlic, onion, oregano, savory, and thyme) after sub-lethal heat stress
Conner 1984 |
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Aspergillis fungus growth is inhibited best by cinnamon and clove, weakly by mustard, caraway seed, or celery seed. Aflatoxin production is inhibited by thyme & oregeno
Llewellyn 1981 |
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"Antispasmodic activity of Origanum compactum " (no abstract) Van Den Broucke 1980 |
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Antifungal activity of Origanum & Ocimum
Afifi 1978 |
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Animal Studies |
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A folk remedy for diabetes, O. onites oil, reduced streptozotocin induced tissue injury without affecting blood glucose levels in rats
Lermioglu 1997 |
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"Antispasmodic activity of Origanum compactum. Part 2: Antagonistic effect of thymol and carvacrol " (no abstract) Van den Broucke 1982 |
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Highest doses of Chamomile, Cinnamon, Absinthium, Mace, Origanum essential oils are depressive to rats while the lowest doses have weak or doubtful effects. Origanum might have action on the CNS
Fundaro 1980 |
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Analytical Chemistry |
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Total tocopherol content was 288 - 672 ppm in Origanum vulgare, Satureja thymbra, Origanum dictamnus and Origanum onites; gamma dominated Lagouri 1996 |
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Tannin of herb teas was highest for mate, tea and oregano (117, 100 & 84 mg/g); medium (20-40 mg/g) for coca, matico, boldo, palto, laurel, orange and binojo and lowest (<10 mg/g) for paico, cedron, apio and manzanilla
Pizarro 1994 |
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The main component of the essential oil of O. cordifolium is alpha-terpineol followed by gamma-terpinene, p-cymene and carvacrol Valentini 1991 |
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Rosmarinic acid is over 3% (dry weight) in Sanicula, Lycopus, Melissa, Mentha, Origanum and Salvia
Lamaison 1990 |
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"Analysis of essential oils in Elsholtzia spledens Nakai ex F Maekawa and Origanum vulgare L " (Chinese, no abstract) Li 1983 |
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Analytical methods for spices: cardamom, laurel, cloves, origanum (marjoram), sage, and thyme, dillseed, coriander, caraway, mace, nutmeg, pimento (allspice), celery seed, capsicum, ginger, pepper, turmeric (curcuma), paprika, garlic, onion, & cinnamon
Salzer 1977 |
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"The terpenoids of various origanum oils " (German, no abstract) Brieskorn 1967 |
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| HISTORY
OF RECORD |
RESEARCHED BY:
Soaring Bear, Ph.D. November 1999 |
RESEARCH UPDATED BY:
Michael C. Tims June 2001 |
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